Studying gap junctions with PARIS
نویسندگان
چکیده
منابع مشابه
Gap Junctions
Gap junctions are sites of intercellular communication where cells are interconnected by small aqueous channels (Figure 1b). The term is morphological, for in transmission electron micrographs of thin sections, the unit membranes of the joined cells are seen to remain separated by a gap of about 2 nm (Figure 1a, inset). The gap of gap junctions distinguishes them from tight junctions, or zonula...
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In vertebrates and invertebrates, signaling among neurons is most commonly mediated by chemical synapses. At these synapses neurotransmitter released by presynaptic neurons is detected by receptors on the postsynaptic neurons, leading to an influx of ions through the receptors themselves or through channels activated by intracellular signaling downstream of the receptors. But neurons can commun...
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Almost since their discovery gap junctions have attracted attention as possible means by which cell growth and cell development could be controlled since they provide for direct cell-cell communication (Potter et al, 1966; Loewenstein, 1968; Sheridan, 1968; Crick, 1970; Bennett, 1973). A corollary, of course, is that gap junctions play an important role in embryogenesis. This idea is made espec...
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Both glycerol and glutaraldehyde, the two most commonly used chemical aids in freeze-fractue studies, have been shown individually to affect the structure of certain membranes as observed in freeze-fracture replicas. The present investigation studied the effect of glycerol on the gap junctions found in a number of tissues from several invertebrate phyla. Glycerol was shown, in some of these tis...
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ژورنال
عنوان ژورنال: eLife
سال: 2019
ISSN: 2050-084X
DOI: 10.7554/elife.45207